A series of gold(I) and gold(III) complexes with N-heterocyclic carbene ligands functionalized with a pendant thioether group (NHC-SR) was synthesized with straightforward procedures and characterized in solution with NMR spectroscopy and ESI-MS spectrometry, as well as in the solid state by means of single crystal X-ray diffraction analysis. Selected experimental aspects were rationalized through relativistic DFT calculations. The gold(I) and gold(III) complexes displayed moderate in vitro cytotoxicity towards breast cancer cells MCF7.
Synthesis, Structural Characterization and Antiproliferative Activity of Gold(I) and Gold(III) Complexes Bearing Thioether-Functionalized N-Heterocyclic Carbenes / De Marco, R.; Dal Grande, M.; Baron, M.; Orian, L.; Graiff, C.; Achard, T.; Bellemin-Laponnaz, S.; Pothig, A.; Tubaro, C.. - In: EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. - ISSN 1434-1948. - 2021:40(2021), pp. 4196-4206. [10.1002/ejic.202100495]
Synthesis, Structural Characterization and Antiproliferative Activity of Gold(I) and Gold(III) Complexes Bearing Thioether-Functionalized N-Heterocyclic Carbenes
De Marco R.;Graiff C.;
2021-01-01
Abstract
A series of gold(I) and gold(III) complexes with N-heterocyclic carbene ligands functionalized with a pendant thioether group (NHC-SR) was synthesized with straightforward procedures and characterized in solution with NMR spectroscopy and ESI-MS spectrometry, as well as in the solid state by means of single crystal X-ray diffraction analysis. Selected experimental aspects were rationalized through relativistic DFT calculations. The gold(I) and gold(III) complexes displayed moderate in vitro cytotoxicity towards breast cancer cells MCF7.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
