A small library of dinuclear gold(i) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting a rigid metallamacrocyclic structure can exhibit rather strong emissions that extend towards the red region of the visible spectrum. Thein vitroanticancer activity of the complexes has been also preliminarly evaluated; cytotoxicity seems to correlate with complex lipophilicity, whereas selectivity towards cancer cells can be apparently enhanced upon a judicious choice of the ligands.
Dinuclear gold(i) complexes withN-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity / Trevisan, G.; Vitali, V.; Tubaro, C.; Graiff, C.; Marchenko, A.; Koidan, G.; Hurieva, A. N.; Kostyuk, A.; Mauceri, M.; Rizzolio, F.; Accorsi, G.; Biffis, A.. - In: DALTON TRANSACTIONS. - ISSN 1477-9226. - 50:38(2021), pp. 13554-13560. [10.1039/d1dt02444b]
Dinuclear gold(i) complexes withN-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity
Graiff C.;Accorsi G.;
2021-01-01
Abstract
A small library of dinuclear gold(i) complexes with the title ligands has been prepared, encompassing neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state have been evaluated, and it turns out that neutral and monocationic complexes not presenting a rigid metallamacrocyclic structure can exhibit rather strong emissions that extend towards the red region of the visible spectrum. Thein vitroanticancer activity of the complexes has been also preliminarly evaluated; cytotoxicity seems to correlate with complex lipophilicity, whereas selectivity towards cancer cells can be apparently enhanced upon a judicious choice of the ligands.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
