Background: Premature rupture of membranes (PROM) is caused by collagen damage in the chorioamniotic sac leading to tearing. Reactive oxygen species (ROS) may be the cause of collagen damage. Isoprostanes (F2-IP) are produced by ROS attack on polyunsaturated fatty acids and are sensitive and specific biomarkers of lipid-peroxidation in vivo. Aim: To verify whether oxidative stress occurs in pregnancies associated with preterm PROM. Methods: F2-IPs were measured in amniotic fluid of 16 pregnancies with preterm PROM (Group II) and 97 without PROM (Group I). Results: F2-IP concentrations (pg/mL) were significantly higher in group II than group I (p < 0.0001). The ROC curve showed a sensitivity of 100% and a specificity of 84.5% at a cut-off of 124.4 pg/mL. Conclusions: An association exists between oxidative stress in pregnancy and preterm PROM. The detection of amniotic fluid F2-IP concentrations seems to be a reliable predictive index of risk of preterm PROM. © 2007 The Canadian Society of Clinical Chemists.
Association between oxidative stress in pregnancy and preterm premature rupture of membranes / Longini, M.; Perrone, S.; Vezzosi, P.; Marzocchi, B.; Kenanidis, A.; Centini, G.; Rosignoli, L.; Buonocore, G.. - In: CLINICAL BIOCHEMISTRY. - ISSN 0009-9120. - 40:11(2007), pp. 793-797. [10.1016/j.clinbiochem.2007.03.004]
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