Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by Wickerhamomyces anomalus and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described.
Wickerhamomyces yeast killer toxins’ medical applications / Giovati, L.; Ciociola, T.; De Simone, T.; Conti, S.; Magliani, W.. - In: TOXINS. - ISSN 2072-6651. - 13:9(2021), p. 655.655. [10.3390/toxins13090655]
Wickerhamomyces yeast killer toxins’ medical applications
Giovati L.Conceptualization
;Ciociola T.Writing – Original Draft Preparation
;De Simone T.Writing – Original Draft Preparation
;Conti S.
Writing – Review & Editing
;Magliani W.Conceptualization
2021-01-01
Abstract
Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by Wickerhamomyces anomalus and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs and their use as potential anti-infective therapeutics. Studies on immunological derivatives of KTs in the context of vaccine development are also described.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
