Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.

Impact of dietary lipids on the reverse cholesterol transport: What we learned from animal studies / Papotti, B.; Escola-Gil, J. C.; Julve, J.; Poti, F.; Zanotti, I.. - In: NUTRIENTS. - ISSN 2072-6643. - 13:8(2021), p. 2643.2643. [10.3390/nu13082643]

Impact of dietary lipids on the reverse cholesterol transport: What we learned from animal studies

Papotti B.;Poti F.;Zanotti I.
2021

Abstract

Reverse cholesterol transport (RCT) is a physiological mechanism protecting cells from an excessive accumulation of cholesterol. When this process begins in vascular macrophages, it acquires antiatherogenic properties, as has been widely demonstrated in animal models. Dietary lipids, despite representing a fundamental source of energy and exerting multiple biological functions, may induce detrimental effects on cardiovascular health. In the present review we summarize the current knowledge on the mechanisms of action of the most relevant classes of dietary lipids, such as fatty acids, sterols and liposoluble vitamins, with effects on different steps of RCT. We also provide a critical analysis of data obtained from experimental models which can serve as a valuable tool to clarify the effects of dietary lipids on cardiovascular disease.
Impact of dietary lipids on the reverse cholesterol transport: What we learned from animal studies / Papotti, B.; Escola-Gil, J. C.; Julve, J.; Poti, F.; Zanotti, I.. - In: NUTRIENTS. - ISSN 2072-6643. - 13:8(2021), p. 2643.2643. [10.3390/nu13082643]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2898199
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact