SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.

Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy / Castelli, M.; Baj, A.; Criscuolo, E.; Ferrarese, R.; Diotti, R. A.; Sampaolo, M.; Novazzi, F.; Dalla Gasperina, D.; Focosi, D.; Ferrari, D.; Locatelli, M.; Clementi, M.; Clementi, N.; Maggi, F.; Mancini, N.. - In: VIRUSES. - ISSN 1999-4915. - 13:8(2021), p. 1514.1530. [10.3390/v13081530]

Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy

Ferrari D.;
2021-01-01

Abstract

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
2021
Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy / Castelli, M.; Baj, A.; Criscuolo, E.; Ferrarese, R.; Diotti, R. A.; Sampaolo, M.; Novazzi, F.; Dalla Gasperina, D.; Focosi, D.; Ferrari, D.; Locatelli, M.; Clementi, M.; Clementi, N.; Maggi, F.; Mancini, N.. - In: VIRUSES. - ISSN 1999-4915. - 13:8(2021), p. 1514.1530. [10.3390/v13081530]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2896301
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 10
  • ???jsp.display-item.citation.isi??? ND
social impact