SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy / Castelli, M.; Baj, A.; Criscuolo, E.; Ferrarese, R.; Diotti, R. A.; Sampaolo, M.; Novazzi, F.; Dalla Gasperina, D.; Focosi, D.; Ferrari, D.; Locatelli, M.; Clementi, M.; Clementi, N.; Maggi, F.; Mancini, N.. - In: VIRUSES. - ISSN 1999-4915. - 13:8(2021), p. 1514.1530. [10.3390/v13081530]
Characterization of a lineage c.36 sars-cov-2 isolate with reduced susceptibility to neutralization circulating in lombardy, italy
Ferrari D.;
2021-01-01
Abstract
SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral re-sponse. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with ad-vantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
