In-depth characterization of heart-brain communication in critically ill patients with severe acute respiratory failure is attracting significant interest in the COronaVIrus Disease 19 (COVID-19) pandemic era during intensive care unit (ICU) stay and after ICU or hospital discharge. Emerging research has provided new insights into pathogenic role of the deregulation of the heart-brain axis (HBA), a bidirectional flow of information, in leading to severe multiorgan disease syndrome (MODS) in patients with confirmed infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Noteworthy, HBA dysfunction may worsen the outcome of the COVID-19 patients. In this review, we discuss the critical role HBA plays in both promoting and limiting MODS in COVID-19. We also highlight the role of HBA as new target for novel therapeutic strategies in COVID-19 in order to open new translational frontiers of care. This is a translational perspective from the Italian Society of Cardiovascular Researches.
Understanding the heart-brain axis response in COVID-19 patients: A suggestive perspective for therapeutic development / Lionetti, V.; Bollini, S.; Coppini, R.; Gerbino, A.; Ghigo, A.; Iaccarino, G.; Madonna, R.; Mangiacapra, F.; Miragoli, M.; Moccia, F.; Munaron, L.; Pagliaro, P.; Parenti, A.; Pasqua, T.; Penna, C.; Quaini, F.; Rocca, C.; Samaja, M.; Sartiani, L.; Soda, T.; Tocchetti, C. G.; Angelone, T.. - In: PHARMACOLOGICAL RESEARCH. - ISSN 1043-6618. - 168(2021). [10.1016/j.phrs.2021.105581]
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