The present invention relates to an antibody capable of binding with highaffinity and high selectivity to the ectodomain of the transmembrane proteoglycan (PG) NG2/CSPG4. The invention specifically refers to said antibody possessing the ability to uniquely induce programmed cell death through canonical caspase-dependent apoptosis or authophagy, 5 in cancer cells specifically expressing such protein, and without the participation of other exogenously added factors. Moreover, the present invention refers to a composition comprising the antibody of the invention as pharmaceutical excipients.

Pro-apoptotic anti-NG2/CSPG4 antibodies and their uses in disease therapy / Perris, R; Dallatomasina, A; Tamburini, E; NicolosiPA, ; Mucignat, Mt. - ELETTRONICO. - (2016).

Pro-apoptotic anti-NG2/CSPG4 antibodies and their uses in disease therapy

Perris R;Dallatomasina A;Tamburini E;
2016

Abstract

The present invention relates to an antibody capable of binding with highaffinity and high selectivity to the ectodomain of the transmembrane proteoglycan (PG) NG2/CSPG4. The invention specifically refers to said antibody possessing the ability to uniquely induce programmed cell death through canonical caspase-dependent apoptosis or authophagy, 5 in cancer cells specifically expressing such protein, and without the participation of other exogenously added factors. Moreover, the present invention refers to a composition comprising the antibody of the invention as pharmaceutical excipients.
Pro-apoptotic anti-NG2/CSPG4 antibodies and their uses in disease therapy / Perris, R; Dallatomasina, A; Tamburini, E; NicolosiPA, ; Mucignat, Mt. - ELETTRONICO. - (2016).
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2891268
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