To evaluate the change over time of vision-related quality of life (QoL) and glaucoma symptoms in a population of newly-diagnosed primary open angle glaucoma (POAG) patients. Multicenter, prospective study. Consecutive newly-diagnosed POAG patients were enrolled and followed-up for one year. Follow-up visits were scheduled at 6 and 12 months from baseline. At each visit, vision-related QoL and glaucoma-related symptoms were assessed by the means of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and the Glaucoma Symptom Scale (GSS), respectively. Trends over time for NEI-VFQ-25 and GSS scores were evaluated with longitudinal linear mixed models. One-hundred seventy-eight patients were included in the analysis. At baseline, early to moderate glaucoma stages were associated with higher scores for most GSS and NEI-VFQ-25 items, while lower best-corrected visual acuity was associated with lower scores for 4 of the 12 NEI-VFQ-25 items. During the follow-up, all the GSS scores, the NEI-VFQ-25 total score, and 7 of the 12 NEI-VFQ-25 scores significantly improved (p < 0.05). In multivariate model, higher increases of most GSS and NEI-VFQ-25 scores were modeled in patients with low scores at baseline. Vision-related QoL and glaucoma-related symptom perception significantly improved during the one-year follow-up in this population of newly diagnosed POAG patients.
Vision-related quality of life and symptom perception change over time in newly-diagnosed primary open angle glaucoma patients / Riva, I.; Legramandi, L.; Rulli, E.; Konstas, A. G.; Katsanos, A.; Oddone, F.; Weinreb, R. N.; Quaranta, L.; Varano, L.; Carchedi, T.; Talarico, S.; Parravano, F.; Motolese, I.; Bagaglia, S. A.; Rossi, G. C. M.; Lateri, S.; Bossolesi, L.; Carmassi, L.; Rolle, T.; Piccini, R.; Ratiglia, R.; Rossi, A.; Gandolfi, S.; Tagliavini, ; Ungaro, N.; Fossarello, M.; Cuccu, A.; Zucca, I.; Uva, M.; Bonacci, E.; Cardarella, G.; Tognetto, D.; Vattovani, O.; Vallon, P.; Iannacone, F.; Fontana, L.; Marchi, S.; Manni, G. L.; Jannetta, D.; Roberti, G.; Rossetti, L.; Maggiolo, E.; Oneta, O.; Sborgia, C.; Cantatore, F.; Mastropasqua, L.; Agnifili, L.; Campos, E.; Gizzi, C.; Giannaccare, G.; Pucci, ; Cassamali, M.; Costagliola, C.; Traverso, C.; Scotto, R.; Musolino, M.; Landi, L.; Bagnis, A.. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 9:1(2019), p. 6735. [10.1038/s41598-019-43203-9]
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