INTRODUCTION: for the management of patients referred to respiratory triage during the early stages of the SARS-CoV-2 pandemic, either chest radiograph (CXR) or computed tomography (CT) were used as first-line diagnostic tools. The aim of this study was to compare the impact on triage, diagnosis and prognosis of patients with suspected COVID-19 when clinical decisions are derived from reconstructed CXR or from CT.METHODS: we reconstructed CXR (r-CXR) from high-resolution CT (HRCT) scan. Five clinical observers independently reviewed clinical charts of 300 subjects with suspected COVID-19 pneumonia, integrated with either r-CXR or HRCT report in two consecutive blinded and randomised sessions: clinical decisions were recorded for each session. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and prognostic value were compared between r-CXR and HRCT. The best radiological integration was also examined to develop an optimised respiratory triage algorithm.RESULTS: interobserver agreement was fair (Kendall's W=0.365; p<0.001) by r-CXR-based protocol and good (Kendall's W=0.654; p<0.001) by CT-based protocol. NPV assisted by r-CXR (31.4%) was lower than that of HRCT (77.9%). In case of indeterminate or typical radiological appearence for COVID-19 pneumonia, extent of disease on r-CXR or HRCT were the only two imaging variables that were similarly linked to mortality by adjusted multivariable models CONCLUSIONS: the present findings suggest that clinical triage is safely assisted by CXR. An integrated algorithm using first-line CXR and contingent use of HRCT can help optimise management and prognostication of COVID-19.

Chest x-ray or CT for COVID-19 pneumonia? Comparative study in a simulated triage setting / Sverzellati, Nicola; Ryerson, Christopher J; Milanese, Gianluca; Renzoni, Elisabetta A; Volpi, Annalisa; Spagnolo, Paolo; Bonella, Francesco; Comelli, Ivan; Affanni, Paola; Veronesi, Licia; Manna, Carmelinda; Ciuni, Andrea; Sartorio, Carlotta; Tringali, Giulia; Silva, Mario; Michieletti, Emanuele; Colombi, Davide; Wells, Athol U. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - (2021), p. 2004188. [10.1183/13993003.04188-2020]

Chest x-ray or CT for COVID-19 pneumonia? Comparative study in a simulated triage setting

Sverzellati, Nicola
Conceptualization
;
Milanese, Gianluca
Data Curation
;
Comelli, Ivan;Affanni, Paola
Data Curation
;
Veronesi, Licia
Data Curation
;
Manna, Carmelinda
Investigation
;
Ciuni, Andrea
Investigation
;
Sartorio, Carlotta
Data Curation
;
Tringali, Giulia
Data Curation
;
Silva, Mario
Supervision
;
Colombi, Davide
Investigation
;
2021

Abstract

INTRODUCTION: for the management of patients referred to respiratory triage during the early stages of the SARS-CoV-2 pandemic, either chest radiograph (CXR) or computed tomography (CT) were used as first-line diagnostic tools. The aim of this study was to compare the impact on triage, diagnosis and prognosis of patients with suspected COVID-19 when clinical decisions are derived from reconstructed CXR or from CT.METHODS: we reconstructed CXR (r-CXR) from high-resolution CT (HRCT) scan. Five clinical observers independently reviewed clinical charts of 300 subjects with suspected COVID-19 pneumonia, integrated with either r-CXR or HRCT report in two consecutive blinded and randomised sessions: clinical decisions were recorded for each session. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and prognostic value were compared between r-CXR and HRCT. The best radiological integration was also examined to develop an optimised respiratory triage algorithm.RESULTS: interobserver agreement was fair (Kendall's W=0.365; p<0.001) by r-CXR-based protocol and good (Kendall's W=0.654; p<0.001) by CT-based protocol. NPV assisted by r-CXR (31.4%) was lower than that of HRCT (77.9%). In case of indeterminate or typical radiological appearence for COVID-19 pneumonia, extent of disease on r-CXR or HRCT were the only two imaging variables that were similarly linked to mortality by adjusted multivariable models CONCLUSIONS: the present findings suggest that clinical triage is safely assisted by CXR. An integrated algorithm using first-line CXR and contingent use of HRCT can help optimise management and prognostication of COVID-19.
Chest x-ray or CT for COVID-19 pneumonia? Comparative study in a simulated triage setting / Sverzellati, Nicola; Ryerson, Christopher J; Milanese, Gianluca; Renzoni, Elisabetta A; Volpi, Annalisa; Spagnolo, Paolo; Bonella, Francesco; Comelli, Ivan; Affanni, Paola; Veronesi, Licia; Manna, Carmelinda; Ciuni, Andrea; Sartorio, Carlotta; Tringali, Giulia; Silva, Mario; Michieletti, Emanuele; Colombi, Davide; Wells, Athol U. - In: EUROPEAN RESPIRATORY JOURNAL. - ISSN 0903-1936. - (2021), p. 2004188. [10.1183/13993003.04188-2020]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2889459
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