Abstract: Free- radicals (Oxygen and Nitrogen species) are formed in mitochondria during the 17 oxidative phosphorylation. Their high reactivity, due to not-engaged electrons, leads to an 18 increase of the oxidative stress. This condition affects above all the brain, that usually needs a large 19 oxygen amount and in which there is the major possibility to accumulate "Reacting Species". 20 Antioxidant molecules are fundamental in limiting free-radical damage, in particular in the central 21 nervous system: the oxidative stress, in fact, seems to worsen the course of neurodegenerative 22 diseases. 23 The aim of this review is to sum up antioxidant molecules with the greatest neuroprotective 24 properties and the role of physical activity against free radical genesis, understanding their 25 relationship with the Central Nervous System.
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