It is now clear that keratinocytes produce a wide range of cytokines that can be regarded as important mediators of intercellular communication. A major emphasis has been placed on IL-1 because of its relationships with other cytokines and other differentiated tissues. Dysregulation of IL-1, IL-1 receptor, and inhibitory factors for IL-1 may cause imbalance of skin biology, leading to perpetuation of immune and inflammatory events. Interaction of IL-1 with other cytokines in vivo is also important in the understanding of the pathophysiology of skin diseases. More fundamental questions regarding the homeostatic significance of IL-1 in keratinocytes still remain to be answered.
Keratinocyte cytokines / Nozaki, S.; Feliciani, C.; Sauder, D. N.. - In: ADVANCES IN DERMATOLOGY. - ISSN 0882-0880. - 7:(1992), pp. 83-101.
Keratinocyte cytokines
Feliciani C.Writing – Original Draft Preparation
;
1992-01-01
Abstract
It is now clear that keratinocytes produce a wide range of cytokines that can be regarded as important mediators of intercellular communication. A major emphasis has been placed on IL-1 because of its relationships with other cytokines and other differentiated tissues. Dysregulation of IL-1, IL-1 receptor, and inhibitory factors for IL-1 may cause imbalance of skin biology, leading to perpetuation of immune and inflammatory events. Interaction of IL-1 with other cytokines in vivo is also important in the understanding of the pathophysiology of skin diseases. More fundamental questions regarding the homeostatic significance of IL-1 in keratinocytes still remain to be answered.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
