Aims The CLIMA study, on the relationship between coronary plaque morphology of the left anterior descending artery and twelve months clinical outcome, was designed to explore the predictive value of multiple high-risk plaque features in the same coronary lesion [minimum lumen area (MLA), fibrous cap thickness (FCT), lipid arc circumferential extension, and presence of optical coherence tomography (OCT)-defined macrophages] as detected by OCT. Composite of cardiac death and target segment myocardial infarction was the primary clinical endpoint. Methods From January 2013 to December 2016, 1003 patients undergoing OCT evaluation of the untreated proximal left and results anterior descending coronary artery in the context of clinically indicated coronary angiogram were prospectively enrolled at 11 independent centres (clinicaltrial.gov identifier NCT02883088). At 1-year, the primary clinical endpoint was observed in 37 patients (3.7%). In a total of 1776 lipid plaques, presence of MLA <3.5 mm2 [hazard ratio (HR) 2.1, 95% confidence interval (CI) 1.1-4.0], FCT <75 mm (HR 4.7, 95% CI 2.4-9.0), lipid arc circumferential extension >180 (HR 2.4, 95% CI 1.2-4.8), and OCT-defined macrophages (HR 2.7, 95% CI 1.2-6.1) were all associated with increased risk of the primary endpoint. The pre-specified combination of plaque features (simultaneous presence of the four OCT criteria in the same plaque) was observed in 18.9% of patients experiencing the primary endpoint and was an independent predictor of events (HR 7.54, 95% CI 3.1-18.6). Conclusion The simultaneous presence of four high-risk OCT plaque features was found to be associated with a higher risk of major coronary events.

Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: The CLIMA study / Prati, F.; Romagnoli, E.; Gatto, L.; Manna, A. L.; Burzotta, F.; Ozaki, Y.; Marco, V.; Boi, A.; Fineschi, M.; Fabbiocchi, F.; Taglieri, N.; Niccoli, G.; Trani, C.; Versaci, F.; Calligaris, G.; Ruscica, G.; Di Giorgio, A.; Vergallo, R.; Albertucci, M.; Biondi-Zoccai, G.; Tamburino, C.; Crea, F.; Alfonso, F.; Arbustini, E.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 41:3(2020), pp. 383-391. [10.1093/eurheartj/ehz520]

Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: The CLIMA study

Gatto L.;Niccoli G.;
2020

Abstract

Aims The CLIMA study, on the relationship between coronary plaque morphology of the left anterior descending artery and twelve months clinical outcome, was designed to explore the predictive value of multiple high-risk plaque features in the same coronary lesion [minimum lumen area (MLA), fibrous cap thickness (FCT), lipid arc circumferential extension, and presence of optical coherence tomography (OCT)-defined macrophages] as detected by OCT. Composite of cardiac death and target segment myocardial infarction was the primary clinical endpoint. Methods From January 2013 to December 2016, 1003 patients undergoing OCT evaluation of the untreated proximal left and results anterior descending coronary artery in the context of clinically indicated coronary angiogram were prospectively enrolled at 11 independent centres (clinicaltrial.gov identifier NCT02883088). At 1-year, the primary clinical endpoint was observed in 37 patients (3.7%). In a total of 1776 lipid plaques, presence of MLA <3.5 mm2 [hazard ratio (HR) 2.1, 95% confidence interval (CI) 1.1-4.0], FCT <75 mm (HR 4.7, 95% CI 2.4-9.0), lipid arc circumferential extension >180 (HR 2.4, 95% CI 1.2-4.8), and OCT-defined macrophages (HR 2.7, 95% CI 1.2-6.1) were all associated with increased risk of the primary endpoint. The pre-specified combination of plaque features (simultaneous presence of the four OCT criteria in the same plaque) was observed in 18.9% of patients experiencing the primary endpoint and was an independent predictor of events (HR 7.54, 95% CI 3.1-18.6). Conclusion The simultaneous presence of four high-risk OCT plaque features was found to be associated with a higher risk of major coronary events.
Relationship between coronary plaque morphology of the left anterior descending artery and 12 months clinical outcome: The CLIMA study / Prati, F.; Romagnoli, E.; Gatto, L.; Manna, A. L.; Burzotta, F.; Ozaki, Y.; Marco, V.; Boi, A.; Fineschi, M.; Fabbiocchi, F.; Taglieri, N.; Niccoli, G.; Trani, C.; Versaci, F.; Calligaris, G.; Ruscica, G.; Di Giorgio, A.; Vergallo, R.; Albertucci, M.; Biondi-Zoccai, G.; Tamburino, C.; Crea, F.; Alfonso, F.; Arbustini, E.. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 41:3(2020), pp. 383-391. [10.1093/eurheartj/ehz520]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2885522
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 125
  • ???jsp.display-item.citation.isi??? 126
social impact