In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.
Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study / Saccomani, M. P.; Cobelli, C.; Gabana, A.; Ferrannini, E.; Bonadonna, R.; Gelfand, R. A.; De Fronzo, R. A.. - 1(1989), pp. 345-350. (Intervento presentato al convegno IFAC Symposium on Modelling and Control in Biomedical Systems tenutosi a Venice, Italy, nel 1988).
Modeling glucose kinetics in vivo in the human forearm. Rationale and a dual tracer study
Bonadonna R.;
1989-01-01
Abstract
In vivo evaluation in humans of transport and metabolism of substrates in skeletal muscle of the forearm is important but difficult. Available approaches are briefly reviewed. In this paper we first outline a general modeling strategy to address this issue in the context of multiple tracer experiment design. A partly-flow compartmental model to assess the kinetics of glucose transport from a dual-tracer study is then presented. The effect of insulin is examined.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
