Purpose: To investigate the association at baseline between plasma levels of selected vitamins and the presence and type of cataract in the participants in The Italian-American Trial of Nutritional Supplements and Age-related Cataract. Methods: At baseline, the participants (1020, 710 with "early cataract" and 310 with "no cataract," 55-75 years of age) received an ocular examination, photographic lens grading, and measurement of plasma levels of vitamins A, C, E, beta-carotene, and of red blood cell glutathione reductase activity. Results: In multiple logistic models adjusted for potential confounders, high vitamin C levels were associated with a protective effect on nuclear (N) [OR: 0.54; 95% CI: 0.30, 0.97] and posterior subcapsular (PSC) cataract (OR: 0.37; 95% CI: 0.15, 0.93). High vitamin E levels were associated with increased prevalence of cortical cataract (C) (OR: 1.99; 95% CI: 1.02-3.90), PSC (OR: 3.27; 95% CI: 1.34, 7.96) and of any cataract (OR: 1.86; 95% CI: 1.08, 3.18). Conclusions: In agreement with some earlier studies, we found higher plasma levels of vitamin C to be associated with reduced prevalence of N and PSC cataracts. The finding of an increased prevalence of some types of cataract with higher levels of vitamin E was unexpected, has not been previously reported, and could be due to unadjusted confounding. Copyright © Taylor & Francis Inc.

Associations between plasma levels of vitamins and cataract in the Italian-American Clinical Trial of Nutritional Supplements and age-related cataract (CTNS): CTNS Report #2 / Ferrigno, L.; Aldigeri, R.; Rosmini, F.; Sperduto, R. D.; Maraini, G.. - In: OPHTHALMIC EPIDEMIOLOGY. - ISSN 0928-6586. - 12:2(2005), pp. 71-80. [10.1080/09286580590932815]

Associations between plasma levels of vitamins and cataract in the Italian-American Clinical Trial of Nutritional Supplements and age-related cataract (CTNS): CTNS Report #2

Aldigeri R.;Maraini G.
2005

Abstract

Purpose: To investigate the association at baseline between plasma levels of selected vitamins and the presence and type of cataract in the participants in The Italian-American Trial of Nutritional Supplements and Age-related Cataract. Methods: At baseline, the participants (1020, 710 with "early cataract" and 310 with "no cataract," 55-75 years of age) received an ocular examination, photographic lens grading, and measurement of plasma levels of vitamins A, C, E, beta-carotene, and of red blood cell glutathione reductase activity. Results: In multiple logistic models adjusted for potential confounders, high vitamin C levels were associated with a protective effect on nuclear (N) [OR: 0.54; 95% CI: 0.30, 0.97] and posterior subcapsular (PSC) cataract (OR: 0.37; 95% CI: 0.15, 0.93). High vitamin E levels were associated with increased prevalence of cortical cataract (C) (OR: 1.99; 95% CI: 1.02-3.90), PSC (OR: 3.27; 95% CI: 1.34, 7.96) and of any cataract (OR: 1.86; 95% CI: 1.08, 3.18). Conclusions: In agreement with some earlier studies, we found higher plasma levels of vitamin C to be associated with reduced prevalence of N and PSC cataracts. The finding of an increased prevalence of some types of cataract with higher levels of vitamin E was unexpected, has not been previously reported, and could be due to unadjusted confounding. Copyright © Taylor & Francis Inc.
Associations between plasma levels of vitamins and cataract in the Italian-American Clinical Trial of Nutritional Supplements and age-related cataract (CTNS): CTNS Report #2 / Ferrigno, L.; Aldigeri, R.; Rosmini, F.; Sperduto, R. D.; Maraini, G.. - In: OPHTHALMIC EPIDEMIOLOGY. - ISSN 0928-6586. - 12:2(2005), pp. 71-80. [10.1080/09286580590932815]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2885246
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