Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome / Niccoli, Giampaolo; Apa, Rosanna; Lanzone, Antonio; Liuzzo, Giovanna; Spaziani, Cristina; Sagnella, Francesca; Cosentino, Nicola; Moro, Francesca; Martinez, Daniela; Morciano, Andrea; Baca', Marco; Pazzano, Vincenzo; Gangale, Maria Francesca; Tropea, Anna; Crea, Filippo. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 2011:Giugno(2011), pp. 2651-2654. [10.1016/j.fertnstert.2011.01.129]

CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome

Niccoli, Giampaolo;
2011

Abstract

Women affected by polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. We demonstrated that women with PCOS showed an expansion of CD4+CD28null T cells, an aggressive population of T lymphocytes that has been recently associated with recurrent coronary instability and type 2 diabetes mellitus. This sheds new light on possible mechanisms responsible for the higher rate of cardiovascular disease among women with PCOS.
CD4+CD28null T lymphocytes are expanded in young women with polycystic ovary syndrome / Niccoli, Giampaolo; Apa, Rosanna; Lanzone, Antonio; Liuzzo, Giovanna; Spaziani, Cristina; Sagnella, Francesca; Cosentino, Nicola; Moro, Francesca; Martinez, Daniela; Morciano, Andrea; Baca', Marco; Pazzano, Vincenzo; Gangale, Maria Francesca; Tropea, Anna; Crea, Filippo. - In: FERTILITY AND STERILITY. - ISSN 0015-0282. - 2011:Giugno(2011), pp. 2651-2654. [10.1016/j.fertnstert.2011.01.129]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2883621
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