New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette, Erdmann; Anika, Grosshennig; Braund Peter, S.; Koenig Inke, R.; Christian, Hengstenberg; Hall Alistair, S.; Patrick, Linsel-Nitschke; Sekar, Kathiresan; Ben, Wright; David-Alexandre, Tregouet; Francois, Cambien; Petra, Bruse; Zouhair, Aherrahrou; Wagner Arnika, K.; Klaus, Stark; Schwartz Stephen, M.; Veikko, Salomaa; Roberto, Elosua; Olle, Melander; Voight Benjamin, F.; O'Donnell Christopher, J.; Leena, Peltonen; Siscovick David, S.; David, Altshuler; Merlini Piera Angelica,; Flora, Peyvandi; Luisa, Bernardinelli; Ardissino, D; Arne, Schillert; Stefan, Blankenberg; Tanja, Zeller; Philipp, Wild; Schwarz Daniel, F.; Laurence, Tiret; Claire, Perret; Stefan, Schreiber; El Mokhtari Nour Eddine,; Arne, Schaefer; Winfried, Maerz; Wilfried, Renner; Peter, Bugert; Harald, Klueter; Juergen, Schrezenmeir; Diana, Rubin; Ball Stephen, G.; Balmforth Anthony, J.; H-Erich, Wichmann; Thomas, Meitinger; Marcus, Fischer; Christa, Meisinger; Jens, Baumert; Annette, Peters; Ouwehand Willem, H.; Panos, Deloukas; Thompson John, R.; Andreas, Ziegler; Samani Nilesh, J.; Heribert, Schunkert

doi:10.1038/ng.307

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in similar to 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11). Keywords

New susceptibility locus for coronary artery disease on chromosome 3q22.3 / Erdmann, Jeanette; Grosshennig, Anika; Braund Peter, S.; Koenig Inke, R.; Hengstenberg, Christian; Hall Alistair, S.; Linsel-Nitschke, Patrick; Kathiresan, Sekar; Wright, Ben; Tregouet, David-Alexandre; Cambien, Francois; Bruse, Petra; Aherrahrou, Zouhair; Wagner Arnika, K.; Stark, Klaus; Schwartz Stephen, M.; Salomaa, Veikko; Elosua, Roberto; Melander, Olle; Voight Benjamin, F.; O'Donnell Christopher, J.; Peltonen, Leena; Siscovick David, S.; Altshuler, David; Merlini Piera, Angelica; Peyvandi, Flora; Bernardinelli, Luisa; Ardissino, D; Schillert, Arne; Blankenberg, Stefan; Zeller, Tanja; Wild, Philipp; Schwarz Daniel, F.; Tiret, Laurence; Perret, Claire; Schreiber, Stefan; El Mokhtari Nour, Eddine; Schaefer, Arne; Maerz, Winfried; Renner, Wilfried; Bugert, Peter; Klueter, Harald; Schrezenmeir, Juergen; Rubin, Diana; Ball Stephen, G.; Balmforth Anthony, J.; Wichmann, H-Erich; Meitinger, Thomas; Fischer, Marcus; Meisinger, Christa; Baumert, Jens; Peters, Annette; Ouwehand Willem, H.; Deloukas, Panos; Thompson John, R.; Ziegler, Andreas; Samani Nilesh, J.; Schunkert, Heribert. - In: NATURE GENETICS. - ISSN 1061-4036. - 41:3(2009), pp. 280-282. [10.1038/ng.307]