The oncolytic viruses have shown promising results for the treatment of multiple myeloma. However, the use of human viruses is limited by the patients' antiviral immune response. In this study, we investigated an alternative oncolytic strategy using non-human pathogen viruses as the bovine viral diarrhea virus (BVDV) that were able to interact with CD46.
Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy / Marchica, Valentina; Franceschi, Valentina; Vescovini, Rosanna; Storti, Paola; Vicario, Emanuela; Toscani, Denise; Zorzoli, Alessia; Airoldi, Irma; Dalla Palma, Benedetta; Campanini, Nicoletta; Martella, Eugenia; Mancini, Cristina; Costa, Federica; Donofrio, Gaetano; Giuliani, Nicola. - In: JOURNAL OF HEMATOLOGY & ONCOLOGY. - ISSN 1756-8722. - 13:1(2020), p. 89. [10.1186/s13045-020-00919-w]
Bovine pestivirus is a new alternative virus for multiple myeloma oncolytic virotherapy
Marchica, Valentina;Franceschi, Valentina;Vescovini, Rosanna;Storti, Paola;Vicario, Emanuela;Toscani, Denise;Dalla Palma, Benedetta;Campanini, Nicoletta;Mancini, Cristina;Donofrio, Gaetano;Giuliani, Nicola
2020-01-01
Abstract
The oncolytic viruses have shown promising results for the treatment of multiple myeloma. However, the use of human viruses is limited by the patients' antiviral immune response. In this study, we investigated an alternative oncolytic strategy using non-human pathogen viruses as the bovine viral diarrhea virus (BVDV) that were able to interact with CD46.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
