We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2′-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.
Synthesis of 2′-modified nucleotides / Gallo, M.; Torres, H.; Iribarren, A.. - In: MOLECULES. - ISSN 1420-3049. - 5:5(2000), pp. 727-729. [10.3390/50500727]
Synthesis of 2′-modified nucleotides
Gallo M.;
2000-01-01
Abstract
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2′-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.File in questo prodotto:
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