Lipase-catalysed alcoholysis and hydrolysis of 2',3',5-tri-O- acetyluridine (1a) and 2',3',5'-tri-O-acetyl-2'-C-methyluridine (1b) were studied. Conditions for full and regioselective deacetylation of 1a and 1b are shown in the present work. New compound 2',3'-di-O-acetyl-2'-C- methyluridine (3b) was prepared by regioselective lipase-catalysed deacetylation.
Complete and regioselective deacetylation of peracetylated uridines using a lipase / Iglesias, L. E.; Zinni, M. A.; Gallo, M.; Iribarren, A. M.. - In: BIOTECHNOLOGY LETTERS. - ISSN 0141-5492. - 22:5(2000), pp. 361-365. [10.1023/A:1005620617554]
Complete and regioselective deacetylation of peracetylated uridines using a lipase
Gallo M.;
2000-01-01
Abstract
Lipase-catalysed alcoholysis and hydrolysis of 2',3',5-tri-O- acetyluridine (1a) and 2',3',5'-tri-O-acetyl-2'-C-methyluridine (1b) were studied. Conditions for full and regioselective deacetylation of 1a and 1b are shown in the present work. New compound 2',3'-di-O-acetyl-2'-C- methyluridine (3b) was prepared by regioselective lipase-catalysed deacetylation.File in questo prodotto:
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