The current literature suggests that Fusobacterium nucleatum, a Gram-negative oral anaerobe, may significantly contribute to CRC development. Furthermore, the presence of Fusobacterium nucleatum in CRCs has also been associated with MSI-high status, lower levels of infiltrating T-lymphocytes, and poor clinical outcomes. We believe that the integration of new technologies, including genomics, bioinformatics and systems medicine, may help to better understand how Fusobacterium nucleatum, immunity status, and environmental factors interact in the initiation and progression of CRCs and generate further information regarding prognostic and therapeutics options for this tumor.
Fusobacterium nucleatum and the Immune System in Colorectal Cancer / Borroni, Em; Qehajaj, D; Farinafm, ; Yiu, D; Bresalier, Rs; Chiriva-Internati, M; Mirandola, L; Štifter, S; Laghi, L; Grizzi, F. - In: CURRENT COLORECTAL CANCER REPORTS. - ISSN 1556-3790. - (In corso di stampa), pp. 1-8.
Fusobacterium nucleatum and the Immune System in Colorectal Cancer
Laghi L;
In corso di stampa
Abstract
The current literature suggests that Fusobacterium nucleatum, a Gram-negative oral anaerobe, may significantly contribute to CRC development. Furthermore, the presence of Fusobacterium nucleatum in CRCs has also been associated with MSI-high status, lower levels of infiltrating T-lymphocytes, and poor clinical outcomes. We believe that the integration of new technologies, including genomics, bioinformatics and systems medicine, may help to better understand how Fusobacterium nucleatum, immunity status, and environmental factors interact in the initiation and progression of CRCs and generate further information regarding prognostic and therapeutics options for this tumor.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
