Aim: To evaluate the gene expression changes that occur soon after the active infection of two susceptible cell types with human herpesvirus 8 (HHV-8). Materials & methods: The expression profile of 282 human genes involved in the inflammatory process was investigated in HHV-8 A1 or C3 subtype-infected and mock-infected human epithelial cells and lymphoid cells. Results: The HHV-8-induced transcriptional profiles in the epithelial and lymphoid cells were very different. A robust increase in the expression was found in genes belonging to different categories, especially the categories of inflammation response and signal transduction. Conclusion: These results indicate that during early infection, HHV-8 induces a variety of cell type-specific processes, thus providing infection signatures useful as potential targets for therapeutic intervention.
Modulation of gene expression in Kaposi's sarcoma-associated herpesvirus-infected lymphoid and epithelial cells / Matteoli, B; BROCCOLO, FRANCESCO; Oggioni, M; Scaccino, A; FORMICA, FRANCESCO; Ciccarese, G; Drago, F; FUSETTI, LISA; Esposito, S; Ceccherini Nelli, L.. - In: FUTURE VIROLOGY. - ISSN 1746-0794. - 11:9(2016), pp. 619-629. [10.2217/fvl-2016-0063]
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