We report herein a simple catalytic method for the extensive labeling of alkenyl C–H bonds through the combination of a palladium(0) complex and a carboxylic acid in the presence of deuterium oxide. The reaction can be applied to a variety of terminal alkenes and the best results are obtained with aryl-substituted examples. This method represents a convenient approach for the preparation of extensively labeled chemicals from the cheapest and safest source of deuterium
Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis / Maestri, Giovanni; Camedda, Nicola; Serafino, Andrea; Maggi, Raimondo; Bigi, Franca; Cera, Gianpiero. - In: SYNTHESIS. - ISSN 0039-7881. - 52:12(2020), pp. 1762-1772. [10.1055/s-0039-1690892]
Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis
Maestri, Giovanni
;Camedda, Nicola;Serafino, Andrea;Maggi, Raimondo;Bigi, Franca;Cera, GianpieroConceptualization
2020-01-01
Abstract
We report herein a simple catalytic method for the extensive labeling of alkenyl C–H bonds through the combination of a palladium(0) complex and a carboxylic acid in the presence of deuterium oxide. The reaction can be applied to a variety of terminal alkenes and the best results are obtained with aryl-substituted examples. This method represents a convenient approach for the preparation of extensively labeled chemicals from the cheapest and safest source of deuteriumI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
