We report herein a simple catalytic method for the extensive labeling of alkenyl C–H bonds through the combination of a palladium(0) complex and a carboxylic acid in the presence of deuterium oxide. The reaction can be applied to a variety of terminal alkenes and the best results are obtained with aryl-substituted examples. This method represents a convenient approach for the preparation of extensively labeled chemicals from the cheapest and safest source of deuterium

Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis / Maestri, Giovanni; Camedda, Nicola; Serafino, Andrea; Maggi, Raimondo; Bigi, Franca; Cera, Gianpiero. - In: SYNTHESIS. - ISSN 0039-7881. - 52:12(2020), pp. 1762-1772. [10.1055/s-0039-1690892]

Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis

Maestri, Giovanni
;
Camedda, Nicola;Serafino, Andrea;Maggi, Raimondo;Bigi, Franca;Cera, Gianpiero
Conceptualization
2020

Abstract

We report herein a simple catalytic method for the extensive labeling of alkenyl C–H bonds through the combination of a palladium(0) complex and a carboxylic acid in the presence of deuterium oxide. The reaction can be applied to a variety of terminal alkenes and the best results are obtained with aryl-substituted examples. This method represents a convenient approach for the preparation of extensively labeled chemicals from the cheapest and safest source of deuterium
Functionalization of Alkenyl C–H Bonds with D2O via Pd(0)/Carboxylic Acid Catalysis / Maestri, Giovanni; Camedda, Nicola; Serafino, Andrea; Maggi, Raimondo; Bigi, Franca; Cera, Gianpiero. - In: SYNTHESIS. - ISSN 0039-7881. - 52:12(2020), pp. 1762-1772. [10.1055/s-0039-1690892]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2875457
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