The cancerous cellular state is associated with multiple epigenetic alterations but elucidating the precise order of such alterations during tumorigenic progression and their contributions to the transformed phenotype remains a significant challenge in cancer biology Here we discuss recent findings on how viral oncoproteins exploit specific epigenetic processes to coerce normal cells to replicate when they should remain quiescent-a hallmark of cancer These findings may highlight roles of epigenetic processes in normal biology and shed light on epigenetic events occurring along the path of non-viral neoplastic transformation
Viral manipulation of the host epigenome for oncogenic transformation / Ferrari, R; Berk, Aj; Kurdistani, Sk. - In: NATURE REVIEWS GENETICS. - ISSN 1471-0056. - 10:5(2009), pp. 290-294. [10.1038/nrg2539]
Viral manipulation of the host epigenome for oncogenic transformation
Ferrari R;
2009-01-01
Abstract
The cancerous cellular state is associated with multiple epigenetic alterations but elucidating the precise order of such alterations during tumorigenic progression and their contributions to the transformed phenotype remains a significant challenge in cancer biology Here we discuss recent findings on how viral oncoproteins exploit specific epigenetic processes to coerce normal cells to replicate when they should remain quiescent-a hallmark of cancer These findings may highlight roles of epigenetic processes in normal biology and shed light on epigenetic events occurring along the path of non-viral neoplastic transformationI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
