Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours. © 2012 British Association of Dermatologists.

Changes observed in slow-growing melanomas during long-term dermoscopic monitoring / Terushkin, V.; Dusza, S. W.; Scope, A.; Argenziano, G.; Bahadoran, P.; Cowell, L.; De Giorgi, V.; Ferrara, G.; Kittler, H.; Malvehy, J.; Menzies, S.; Piccolo, D.; Puig, S.; Rubegni, P.; Stanganelli, I.; Thomas, L.; Zalaudek, I.; Marghoob, A. A.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 166:6(2012), pp. 1213-1220. [10.1111/j.1365-2133.2012.10846.x]

Changes observed in slow-growing melanomas during long-term dermoscopic monitoring

Stanganelli I.;
2012-01-01

Abstract

Background: Melanomas vary in growth rate from rapidly developing nodular melanomas to slow-growing melanomas (SGM) that hardly change over years. Objectives: To evaluate longitudinal changes in dermoscopic findings of SGM. Methods We retrospectively analysed a dermoscopic image dataset from 15 pigmented lesion clinics, of SGM that were followed sequentially by digital dermoscopy for at least 1 year. We evaluated baseline and follow-up images for changes in global pattern, organization, colours, structure and size. Results: Our series consisted of 92 SGM. On follow-up, these melanomas developed the following dermoscopic findings: more homogeneous and less reticular global dermoscopic pattern; more frequent disorganization of pattern (baseline, 67% vs. follow-up, 79%); decreased prominence of light brown colour, increased prominence of dark brown colour, and increased frequency of the colours red, white, grey, blue and black (baseline: 29%, 3%, 18%, 6% and 33% vs. follow-up: 41%, 10%, 31%, 13% and 45%, respectively); decrease in prominence of dermoscopic structure of pigmented network, with a concomitant increase in prominence of structureless areas; and increased prominence or new appearance of melanoma-specific dermoscopic structures, including negative network, blue-white structures and blotches. The majority of lesions (75%) remained the same size or grew by < 2 mm in diameter. An increase in lesion size was associated with change in the total number of colours and structures (χ 2 = 14·3, P = 0·027) at follow-up. Conclusions: While their diameter changed minimally over time, most SGM became more disorganized, revealed loss of network in favour of structureless areas, and developed new colours. © 2012 British Association of Dermatologists.
2012
Changes observed in slow-growing melanomas during long-term dermoscopic monitoring / Terushkin, V.; Dusza, S. W.; Scope, A.; Argenziano, G.; Bahadoran, P.; Cowell, L.; De Giorgi, V.; Ferrara, G.; Kittler, H.; Malvehy, J.; Menzies, S.; Piccolo, D.; Puig, S.; Rubegni, P.; Stanganelli, I.; Thomas, L.; Zalaudek, I.; Marghoob, A. A.. - In: BRITISH JOURNAL OF DERMATOLOGY. - ISSN 0007-0963. - 166:6(2012), pp. 1213-1220. [10.1111/j.1365-2133.2012.10846.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2872660
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