Abstract Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof The invention discloses an IL-1 beta vaccine for treating pulmonary fibrosis. A recombinant PfTrx-IL-1 beta vaccine established by inserting epitope of IL-1 beta into a PfTrx carrier sequence can successfully stimulate an organism to generate high-potency IL-1 beta resistant neutralizing antibody and can obviously relieve pulmonary fibrosis induced by bleomycin. Immunity of the IL-1 beta vaccine can obviously inhibit mouse pulmonary tissue collagen deposition, the vaccine can lower expression level of TGF-beta 1, CTGF and PDGFB in mouse, and these characteristics are highly conducive to slowing down the process of pulmonary fibrosis. Therefore, the IL-1 beta vaccine is expected to be developed into an effective means for treating pulmonary fibrosis.
Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof (CN108404125B) / Zhaoyang, Hao; Zhiming, Hao; Hanchao, Li; Qian, Li; Ottonello, Simone; Xiaoyan, Zheng. - ELETTRONICO. - (2019).
Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof (CN108404125B)
SIMONE OTTONELLO;
2019-01-01
Abstract
Abstract Interleukin 1 beta recombinant vaccine for treating pulmonary fibrosis and application thereof The invention discloses an IL-1 beta vaccine for treating pulmonary fibrosis. A recombinant PfTrx-IL-1 beta vaccine established by inserting epitope of IL-1 beta into a PfTrx carrier sequence can successfully stimulate an organism to generate high-potency IL-1 beta resistant neutralizing antibody and can obviously relieve pulmonary fibrosis induced by bleomycin. Immunity of the IL-1 beta vaccine can obviously inhibit mouse pulmonary tissue collagen deposition, the vaccine can lower expression level of TGF-beta 1, CTGF and PDGFB in mouse, and these characteristics are highly conducive to slowing down the process of pulmonary fibrosis. Therefore, the IL-1 beta vaccine is expected to be developed into an effective means for treating pulmonary fibrosis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
