Background: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer. Case presentation: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. A clonal T-cell proliferation and CD30 negative immunohistochemical (IHC) profile could be documented. Discussion and conclusion: In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patient did not report signs of recurrence after a 3-year follow-up period.

Self-healing CD30- T-clonal proliferation of the tongue: Report of an extremely rare case / Setti, G.; Martella, E.; Mancini, C.; Vescovi, P.; Magnoni, C.; Bellini, P.; Giovannacci, I.; Meleti, M.. - In: BMC ORAL HEALTH. - ISSN 1472-6831. - 19:1(2019), p. 186. [10.1186/s12903-019-0875-5]

Self-healing CD30- T-clonal proliferation of the tongue: Report of an extremely rare case

Setti G.;Vescovi P.;Giovannacci I.;Meleti M.
2019-01-01

Abstract

Background: The etiology of traumatic ulcerative granulomas with stromal eosinophilia (TUGSE) is not clear, traumatic irritation having advocated as the most likely cause. TUGSEs are typically self-limiting slow-healing lesions of the oral mucosa with unclear pathogenesis, commonly manifesting as a rapidly developing, long-lasting ulcer. Case presentation: Here we report a controversial case of a self-healing lesion of the tongue in a 57 year-old woman. A clonal T-cell proliferation and CD30 negative immunohistochemical (IHC) profile could be documented. Discussion and conclusion: In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patient did not report signs of recurrence after a 3-year follow-up period.
Self-healing CD30- T-clonal proliferation of the tongue: Report of an extremely rare case / Setti, G.; Martella, E.; Mancini, C.; Vescovi, P.; Magnoni, C.; Bellini, P.; Giovannacci, I.; Meleti, M.. - In: BMC ORAL HEALTH. - ISSN 1472-6831. - 19:1(2019), p. 186. [10.1186/s12903-019-0875-5]
File in questo prodotto:
File Dimensione Formato  
12903_2019_Article_875.pdf

accesso aperto

Tipologia: Versione (PDF) editoriale
Licenza: Creative commons
Dimensione 1.73 MB
Formato Adobe PDF
1.73 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2868270
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact