Anti-Apolipoprotein A-1 autoantibodies (anti-ApoA-1 IgG) promote atherogenesis via innate immune receptors, and may impair cellular cholesterol homeostasis (CH). We explored the presence of anti-ApoA-1 IgG in children (5-15 years old) with or without familial hypercholesterolemia (FH), analyzing their association with lipid profiles, and studied their in vitro effects on foam cell formation, gene regulation, and their functional impact on cholesterol passive diffusion (PD).
Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation / Pagano, Sabrina; Magenta, Alessandra; D'Agostino, Marco; Martino, Francesco; Barillà, Francesco; Satta, Nathalie; Frias, Miguel A; Ronca, Annalisa; Mach, François; Gencer, Baris; Favari, Elda; Vuilleumier, Nicolas. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 8:12(2019), p. 2035. [10.3390/jcm8122035]
Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation
Ronca, Annalisa;Favari, Elda;
2019-01-01
Abstract
Anti-Apolipoprotein A-1 autoantibodies (anti-ApoA-1 IgG) promote atherogenesis via innate immune receptors, and may impair cellular cholesterol homeostasis (CH). We explored the presence of anti-ApoA-1 IgG in children (5-15 years old) with or without familial hypercholesterolemia (FH), analyzing their association with lipid profiles, and studied their in vitro effects on foam cell formation, gene regulation, and their functional impact on cholesterol passive diffusion (PD).| File | Dimensione | Formato | |
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