In the last years bioresorbable materials are gaining increasing interest for building implantable optical components for medical devices. In this work we show the fabrication of bioresorbable optical fibers designed for diffuse optics applications, featuring large core diameter (up to 200 μm) and numerical aperture (0.17) to maximize the collection efficiency of diffused light. We demonstrate the suitability of bioresorbable fibers for time-domain diffuse optical spectroscopy firstly checking the intrinsic performances of the setup by acquiring the instrument response function. We then validate on phantoms the use of bioresorbable fibers by applying the MEDPHOT protocol to assess the performance of the system in measuring optical properties (namely, absorption and scattering coefficients) of homogeneous media. Further, we show an ex-vivo validation on a chicken breast by measuring the absorption and scattering spectra in the 500–1100 nm range using interstitially inserted bioresorbable fibers. This work represents a step toward a new way to look inside the body using optical fibers that can be implanted in patients. These fibers could be useful either for diagnostic (e. g. for monitoring the evolution after surgical interventions) or treatment (e. g. photodynamic therapy) purposes.
Towards the use of bioresorbable fibers in time-domain diffuse optics / Di Sieno, Laura; Boetti, NADIA GIOVANNA; Mora, Alberto Dalla; Pugliese, Diego; Farina, Andrea; Konugolu Venkata Sekar, Sanathana; CECI GINISTRELLI, Edoardo; Janner, DAVIDE LUCA; Pifferi, Antonio; Milanese, Daniel. - In: JOURNAL OF BIOPHOTONICS. - ISSN 1864-063X. - 11:1(2018), pp. 1-11. [10.1002/jbio.201600275]
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