RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-β-1b

Iarlori,; And Reale, C. A.; And Lugaresi, M. B.; And De Luca, A. A.; And Bonanni, G. A.; And Di Iorio, L. A.; And, A. C.; Feliciani, C.; And Conti, C. D.; And Gambi, P. B.; D. A.,

doi:10.1016/S0165-5728(00)00261-7

RANTES (regulated upon activation, normal T-cell expressed and secreted), a CC chemokine, appears to play a role in the pathogenesis of relapsing-remitting multiple sclerosis (RR-MS), enhancing the inflammatory response within the nervous system. We have demonstrated that RANTES production is increased in RR-MS compared to controls. Interferon-β-1b (IFN-β-1b) treatment reduces RANTES production in sera and peripheral blood adherent mononuclear cell (PBAM) supernatants both in relapse and remission. IFN-β-1b also reduces RANTES expression in PBAM. Our results suggest that RANTES modulation might represent one of the mechanisms of action of IFN-β-1b in RR-MS. Copyright (C) 2000 Elsevier Science B.V.

RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-β-1b / Iarlori, ., and Reale, C.a., and Lugaresi, M.b., and De Luca, A.a., and Bonanni, G.a., and Di Iorio, L.a., And, A.c., Feliciani, C., and Conti, C.d., and Gambi, P.b., A., D.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 107:1(2000), pp. 100-107. [10.1016/S0165-5728(00)00261-7]