Monocyte chemoattractant protein-1 (MCP-1) seems to be involved in the pathogenesis of multiple sclerosis (MS). We found that in unstimulated (PHA-) and PHA-stimulated (PHA+) peripheral blood mononuclear cells (PBMC), MCP-1 and TNFα levels are higher in stable untreated MS patients. Interferon gamma (IFNγ) is higher in relapsing patients in PHA- cultures and in stable patients in PHA+ cultures. Chronic IFNβ-1b treatment down-regulates TNFα, IFNγ and MCP-1 production except for TNFα in relapsing patients. IFNβ-1b, in vitro, increases MCP-1, TNFα and IFNγ spontaneous production in all patients. Multivariate analysis suggests that MCP-1 production is dependent from clinical status and not from TNFα and IFNγ production. Logistic regression analysis shows that MCP-1 production is significantly modified by treatment. Further studies are needed to clarify the role of MCP-1 in MS. © 2002 Elsevier Science B.V. All rights reserved.
Interferon β-1b modulates MCP-1 expression and production in relapsing-remitting multiple sclerosis / Iarlori, ; a and Reale, C.; b and De Luca, M.; a and Di Iorio, G.; C, A.; Feliciani, C.; d and Tulli, C.; d and Conti, A.; b and Gambi, P.; a and Lugaresi, D.; A, A.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - 123:1-2(2002), pp. 170-179. [10.1016/S0165-5728(01)00487-8]