A trimetallic Cu-II derivative, [Cu-3(L)(2)(CF3COO)(2)] (1) (where H2L = N,N-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu-II ions are linked to the central Cu-II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu-II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.[GRAPHICS].
Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines / Das, K.; Datta, A.; Massera, C.; Roma-Rodrigues, C.; Barroso, M.; Baptista, P. V.; Fernandes, A. R.. - In: JOURNAL OF COORDINATION CHEMISTRY. - ISSN 0095-8972. - 72:5-7(2019), pp. 920-940. [10.1080/00958972.2019.1597973]
Structural aspects of a trimetallic Cu II derivative: cytotoxicity and anti-proliferative activity on human cancer cell lines
Massera C.;
2019-01-01
Abstract
A trimetallic Cu-II derivative, [Cu-3(L)(2)(CF3COO)(2)] (1) (where H2L = N,N-bis(salicylidene)-1,3-propanediamine), was prepared and characterized. In 1, the two terminal Cu-II ions are linked to the central Cu-II by trifluoroacetato and doubly bridging phenoxido. Both the square-pyramidal and octahedral geometries are observed among two different Cu-II centers in the linear arrangement of the trimetallic unit. Compound 1 is characterized by IR and UV-Vis spectra. Compound 1 has high cytotoxic activity in breast adenocarcinoma (MCF-7), colorectal carcinoma (HCT116) and particularly, in ovarian carcinoma (A2780) cell line compared to a lung adenocarcinoma cell line. The IC50 in A2780 cells is 25 times lower than the respective value for normal human primary fibroblasts demonstrating 1 has higher cytotoxicity towards cancer cells. Additionally, combination of DOX with 1 induces a higher loss of HCT116 cell viability compared with each drug alone.[GRAPHICS].I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
