A copper-mediated C-H chalcogenation of triazoles has been achieved by weak coordination. The user-friendly protocol showed high functional-group tolerance and ample substrate scope, yielding fully substituted 1,2,3-triazoles with complete positional site-selectivity. The C-H selenylation could likewise be achieved by means of copper catalysis. Our findings highlight for the first time that weak O-coordination can outcompete the strong N,N-bidentate coordination mode in C-H functionalization technology.

Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper Catalyzed C-H Chalcogenation / Cera, G; Ackermann, L. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 22:25(2016), pp. 8475-8478. [10.1002/chem.201601821]

Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper Catalyzed C-H Chalcogenation

Cera G;
2016-01-01

Abstract

A copper-mediated C-H chalcogenation of triazoles has been achieved by weak coordination. The user-friendly protocol showed high functional-group tolerance and ample substrate scope, yielding fully substituted 1,2,3-triazoles with complete positional site-selectivity. The C-H selenylation could likewise be achieved by means of copper catalysis. Our findings highlight for the first time that weak O-coordination can outcompete the strong N,N-bidentate coordination mode in C-H functionalization technology.
2016
Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper Catalyzed C-H Chalcogenation / Cera, G; Ackermann, L. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 22:25(2016), pp. 8475-8478. [10.1002/chem.201601821]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2865334
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