A copper-mediated C-H chalcogenation of triazoles has been achieved by weak coordination. The user-friendly protocol showed high functional-group tolerance and ample substrate scope, yielding fully substituted 1,2,3-triazoles with complete positional site-selectivity. The C-H selenylation could likewise be achieved by means of copper catalysis. Our findings highlight for the first time that weak O-coordination can outcompete the strong N,N-bidentate coordination mode in C-H functionalization technology.
Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper Catalyzed C-H Chalcogenation / Cera, G; Ackermann, L. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - 22:25(2016), pp. 8475-8478. [10.1002/chem.201601821]
Weak O-Assistance Outcompeting Strong N,N-Bidentate Directing Groups in Copper Catalyzed C-H Chalcogenation
Cera G;
2016-01-01
Abstract
A copper-mediated C-H chalcogenation of triazoles has been achieved by weak coordination. The user-friendly protocol showed high functional-group tolerance and ample substrate scope, yielding fully substituted 1,2,3-triazoles with complete positional site-selectivity. The C-H selenylation could likewise be achieved by means of copper catalysis. Our findings highlight for the first time that weak O-coordination can outcompete the strong N,N-bidentate coordination mode in C-H functionalization technology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.