The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly important
Merging Synthesis and Enantioselectiv e Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction / Chiarucci, M.; Mocci, R.; Syntrivanis, L. -D.; Cera, G.; Mazzanti, A.; Bandini, M.. - In: SYNFACTS. - ISSN 1861-1958. - 10:1(2014), pp. 68-68. [10.1055/s-0033-1340458]
Merging Synthesis and Enantioselectiv e Functionalization of Indoles by a Gold-Catalyzed Asymmetric Cascade Reaction
G. CERA;
2014-01-01
Abstract
The authors developed a gold-cat-alyzed hydroamination followed by an asymmetric nucleophilic allylic substitution cascade to access oxazino[4,3-a]indoles in good yields and enantio-selectivities. Owing to pharmacologically active in- dole alkaloids, this rapid synthesis and asymmet-ric decoration of the polycyclic indolyl core is highly importantFile in questo prodotto:
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