The selective activation/functionalization of benzhydryl CACHTUNGTRENUNG(sp3)H bonds is documented. The gold complex XPhosAuNTf2 turned out to be an efficient catalyst (5 mol%) to transform readily available propargylic esters into di- or trisubstituted naphthalenes in high yield. A 1,5-hydride shift is postulated as the key step of the cascade reaction sequence.
Gold(I)-Catalyzed Functionalization of Benzhydryl C-(sp3)H Bonds / Cera, Gianpiero; Chiarucci, Michel; Dosi, Federico; Bandini, Marco. - In: ADVANCED SYNTHESIS & CATALYSIS. - ISSN 1615-4169. - 355:(2013), pp. 2227-2231. [10.1002/adsc.201300525]
Gold(I)-Catalyzed Functionalization of Benzhydryl C-(sp3)H Bonds
Gianpiero Cera;
2013-01-01
Abstract
The selective activation/functionalization of benzhydryl CACHTUNGTRENUNG(sp3)H bonds is documented. The gold complex XPhosAuNTf2 turned out to be an efficient catalyst (5 mol%) to transform readily available propargylic esters into di- or trisubstituted naphthalenes in high yield. A 1,5-hydride shift is postulated as the key step of the cascade reaction sequence.File in questo prodotto:
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