Objectives: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. Design: Cross-sectional survey. Setting: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). Participants: A total of 1,304 (age-range: 20-103, 79% agedgreater than or equal to65) participants of the InCHIANTI study. Measurements: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G greater than or equal to1/16 and <1/256, and recent CPI was defined as IgG greater than or equal to1/512 or IgM greater than or equal to1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. Results: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P<.01). CPI was not associated with IL-1beta, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-alpha (P<.01), IL-6 (P<.03), sIL-6R (P<.01), and hypertension (P<.02). In additional age and sex-adjusted models, the associations between CPI and TNF-alpha, IL-6, sIL-6r, and hypertension appeared to be mutually independent. Conclusion: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-alpha, IL-6, and sIL-6r.

Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI study / Blanc, P; Corsi, Am; Gabbuti, A; Peduzzi, C; Meacci, F; Olivieri, F; Lauretani, F; Francesco, M; Ferrucci, L. - In: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. - ISSN 0002-8614. - 52:10(2004), pp. 1626-1631. [10.1111/j.1532-5415.2004.52453.x]

Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI study

Lauretani F;
2004-01-01

Abstract

Objectives: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. Design: Cross-sectional survey. Setting: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). Participants: A total of 1,304 (age-range: 20-103, 79% agedgreater than or equal to65) participants of the InCHIANTI study. Measurements: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G greater than or equal to1/16 and <1/256, and recent CPI was defined as IgG greater than or equal to1/512 or IgM greater than or equal to1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. Results: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P<.01). CPI was not associated with IL-1beta, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-alpha (P<.01), IL-6 (P<.03), sIL-6R (P<.01), and hypertension (P<.02). In additional age and sex-adjusted models, the associations between CPI and TNF-alpha, IL-6, sIL-6r, and hypertension appeared to be mutually independent. Conclusion: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-alpha, IL-6, and sIL-6r.
2004
Chlamydia pneumoniae seropositivity and cardiovascular risk factors: The InCHIANTI study / Blanc, P; Corsi, Am; Gabbuti, A; Peduzzi, C; Meacci, F; Olivieri, F; Lauretani, F; Francesco, M; Ferrucci, L. - In: JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. - ISSN 0002-8614. - 52:10(2004), pp. 1626-1631. [10.1111/j.1532-5415.2004.52453.x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2865195
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