Henoch–Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch–Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15 years' medical literature concerning the relationship between infections, genetics, and Henoch–Schönlein purpura in pediatrics.

Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? / Rigante, D.; Castellazzi, L.; Bosco, A.; Esposito, S.. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 12:10(2013), pp. 1016-1021. [10.1016/j.autrev.2013.04.003]

Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura?

S. Esposito
2013-01-01

Abstract

Henoch–Schönlein purpura is the most common systemic vasculitis in childhood, characterized by the presence of immunoglobulin A deposits in the small vessels of skin, gastrointestinal tube, joints and kidneys. Although there have been great efforts made in elucidating its pathogenic mechanisms, Henoch–Schönlein purpura etiology remains unknown: the basic scene comes across an abnormal inflammatory process deriving from immune reactions to various antigenic stimuli, which might be bacterial, viral, or parasitic agents, in a genetically prone individual. Then, a peculiar immune complex deposition in the vascular walls and overproduction of different proinflammatory molecules elicit different clinical signs, which might be differentiated according to either a specific trigger or a specific genetic make-up. The aim of this review is to make a critical appraisal of the last 15 years' medical literature concerning the relationship between infections, genetics, and Henoch–Schönlein purpura in pediatrics.
2013
Is there a crossroad between infections, genetics, and Henoch-Schönlein purpura? / Rigante, D.; Castellazzi, L.; Bosco, A.; Esposito, S.. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 12:10(2013), pp. 1016-1021. [10.1016/j.autrev.2013.04.003]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2864636
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