Group A . Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the . emm gene encoding the M protein, but despite the high number of distinct . emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A . Streptococcus" and "acute rheumatic fever": the prevalence of peculiar . emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific . emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between . emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.

Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever / Esposito, Susanna Maria Roberta; S., Bianchini; M., Fastiggi; M., Fumagalli; L., Andreozzi; D., Rigante. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 14:7(2015), pp. 616-621. [10.1016/j.autrev.2015.03.001]

Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever

Esposito, Susanna Maria Roberta;
2015-01-01

Abstract

Group A . Streptococcus (GAS) strains are lately classified on the basis of sequence variations in the . emm gene encoding the M protein, but despite the high number of distinct . emm genotypes, the spectrum of phenotypes varying from invasive suppurative to non-suppurative GAS-related disorders has still to be defined. The relationship of GAS types with the uprising of acute rheumatic fever (ARF), a multisystemic disease caused by misdirected anti-GAS response in predisposed people, is also obscure. Studies published over the last 15. years were retrieved from PubMed using the keywords: ". Streptococcus pyogenes" or "group A . Streptococcus" and "acute rheumatic fever": the prevalence of peculiar . emm types across different countries of the world is highly variable, depending on research designs, year of observation, country involved, patients' age, and gender. Most studies revealed that a relatively small number of specific . emm/M protein types can be considered "rheumatogenic", as potentially characterized by the possibility of inducing ARF, with remarkable differences between developing and developed countries. The association between . emm types and post-streptococcal manifestations is challenging, however surveillance of disease-causing variants in a specific community with high rate of ARF should be reinforced with the final goal of developing a potential primary prophylaxis against GAS infections.
Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever / Esposito, Susanna Maria Roberta; S., Bianchini; M., Fastiggi; M., Fumagalli; L., Andreozzi; D., Rigante. - In: AUTOIMMUNITY REVIEWS. - ISSN 1568-9972. - 14:7(2015), pp. 616-621. [10.1016/j.autrev.2015.03.001]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2864496
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