Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days in five European countries. Clinical and laboratory findings as well as empiric treatment were recorded and patients were followed until the end of antibiotic therapy. Failure was defined as a change of primary antibiotic, no resolution of clinical signs, appearance of new signs/pathogens or death. Antibiotic therapy was considered appropriate if the organism was susceptible to at least one empiric antibiotic. 113 infants (median age 14 days, 62 % ≤1500 g) were recruited; 61 % were culture proven cases (28 CoNS, 24 Enterobacteriaceae, 11 other Gram-positives and 6 Gram-negative non-fermentative organisms). The predictive value of the expert-panel criteria to identify patients with a culture proven LOS was 61 % (95 % CI 52 % to 70 %). Around one third of Enterobacteriaceae were resistant to ampicillin + or cefotaxime + gentamicin but only 10 % to meropenem. Empiric treatment contained a total of 43 different antibiotic regimens. All-cause mortality was 8 % with an additional 45 % classified as failure of empiric therapy, mainly due to change of primary antibiotics (42/60). Conclusions: The expert panel - derived diagnostic criteria performed well identifying a high rate of culture proven sepsis. Current management of LOS in Europe is extremely variable suggesting an urgent need of evidence-based guidelines.

Current management of late onset neonatal bacterial sepsis in five European countries / I., Lutsar; C., Chazallon; F. I. C., Carducci; U., Trafojer; B., Abdelkader; V. M., de Cabre; Esposito, Susanna Maria Roberta; C., Giaquinto; P. T., Heath; M., Ilmoja; A., Katragkou; C., Lascoux; T., Metsvaht; G., Mitsiakos; E., Netzer; L., Pugni; E., Roilides; Y., Saidi; K., Sarafidis; M., Sharland; V., Usonis; J., Aboulker. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 173:8(2014), pp. 997-1004. [10.1007/s00431-014-2279-5]

Current management of late onset neonatal bacterial sepsis in five European countries

Esposito, Susanna Maria Roberta;
2014

Abstract

Late onset neonatal sepsis (LOS) has a high mortality and the optimal management is poorly defined. We aimed to evaluate new expert panel-derived criteria to define LOS and characterize the current management and antibiotic susceptibility of LOS-causing organisms in Europe. A prospective observational study enrolled infants aged 4 to 90 days in five European countries. Clinical and laboratory findings as well as empiric treatment were recorded and patients were followed until the end of antibiotic therapy. Failure was defined as a change of primary antibiotic, no resolution of clinical signs, appearance of new signs/pathogens or death. Antibiotic therapy was considered appropriate if the organism was susceptible to at least one empiric antibiotic. 113 infants (median age 14 days, 62 % ≤1500 g) were recruited; 61 % were culture proven cases (28 CoNS, 24 Enterobacteriaceae, 11 other Gram-positives and 6 Gram-negative non-fermentative organisms). The predictive value of the expert-panel criteria to identify patients with a culture proven LOS was 61 % (95 % CI 52 % to 70 %). Around one third of Enterobacteriaceae were resistant to ampicillin + or cefotaxime + gentamicin but only 10 % to meropenem. Empiric treatment contained a total of 43 different antibiotic regimens. All-cause mortality was 8 % with an additional 45 % classified as failure of empiric therapy, mainly due to change of primary antibiotics (42/60). Conclusions: The expert panel - derived diagnostic criteria performed well identifying a high rate of culture proven sepsis. Current management of LOS in Europe is extremely variable suggesting an urgent need of evidence-based guidelines.
Current management of late onset neonatal bacterial sepsis in five European countries / I., Lutsar; C., Chazallon; F. I. C., Carducci; U., Trafojer; B., Abdelkader; V. M., de Cabre; Esposito, Susanna Maria Roberta; C., Giaquinto; P. T., Heath; M., Ilmoja; A., Katragkou; C., Lascoux; T., Metsvaht; G., Mitsiakos; E., Netzer; L., Pugni; E., Roilides; Y., Saidi; K., Sarafidis; M., Sharland; V., Usonis; J., Aboulker. - In: EUROPEAN JOURNAL OF PEDIATRICS. - ISSN 0340-6199. - 173:8(2014), pp. 997-1004. [10.1007/s00431-014-2279-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2864321
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