Aim: We investigated outcomes in patients with advanced non-small-cell lung cancer (NSCLC) and peritoneal involvement. Patients & methods: NSCLC patients with peritoneal carcinomatosis (PC) were included. We evaluated mOS1 (overall survival [OS] from NSCLC diagnosis) and mOS2 (OS from diagnosis of PC). Results: In total, 60 NSCLC patients were diagnosed with PC, 12 (20%) patients had a diagnosis of NSCLC and synchronous PC with a median OS of 9 months. Smokers had a shorter mOS1 and mOS2 compared with never-smokers; EGFR-mutated patients on tyrosine kinase inhibitors had longer mOS1 and mOS2 than EGFR wild-type patients. Conclusion: Metachronous PC is correlated to a short survival, irrespective of treatment line. Never-smokers and EGFR-mutated patients had improved mOS1 and mOS2 when compared with smokers and EGFR wild-type population.

Peritoneal carcinomatosis in non-small-cell lung cancer: Retrospective multicentric analysis and literature review / Abbate, M. I.; Cortinovis, D. L.; Tiseo, M.; Vavala, T.; Cerea, G.; Toschi, L.; Canova, S.; Colonese, F.; Bidoli, P.. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 15:9(2019), pp. 989-994. [10.2217/fon-2018-0469]

Peritoneal carcinomatosis in non-small-cell lung cancer: Retrospective multicentric analysis and literature review

Tiseo M.;
2019

Abstract

Aim: We investigated outcomes in patients with advanced non-small-cell lung cancer (NSCLC) and peritoneal involvement. Patients & methods: NSCLC patients with peritoneal carcinomatosis (PC) were included. We evaluated mOS1 (overall survival [OS] from NSCLC diagnosis) and mOS2 (OS from diagnosis of PC). Results: In total, 60 NSCLC patients were diagnosed with PC, 12 (20%) patients had a diagnosis of NSCLC and synchronous PC with a median OS of 9 months. Smokers had a shorter mOS1 and mOS2 compared with never-smokers; EGFR-mutated patients on tyrosine kinase inhibitors had longer mOS1 and mOS2 than EGFR wild-type patients. Conclusion: Metachronous PC is correlated to a short survival, irrespective of treatment line. Never-smokers and EGFR-mutated patients had improved mOS1 and mOS2 when compared with smokers and EGFR wild-type population.
Peritoneal carcinomatosis in non-small-cell lung cancer: Retrospective multicentric analysis and literature review / Abbate, M. I.; Cortinovis, D. L.; Tiseo, M.; Vavala, T.; Cerea, G.; Toschi, L.; Canova, S.; Colonese, F.; Bidoli, P.. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 15:9(2019), pp. 989-994. [10.2217/fon-2018-0469]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2862495
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