Facial aging is a complex process and often poses a challenge for plastic and aesthetic surgeons. Injectable fillers and autologous adipose tissue are widely used for the restoration of soft tissue volume. However, lipotransfer currently lacks standardization and its unpredictable reabsorption rate remains an unresolved issue. Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells that could be responsible for the main rejuvenation capabilities of fat grafts. Currently, ASCs are administered in conjunction with autologous fat, while injectable vehicles such as hyaluronic acid, or other injectable biomaterials, are under study for the treatment of facial aging with promising results. Indeed, bioengineered fillers are at a very early stage of development, and could be further developed as semi-permanent fillers with biological properties of engrafted adipose tissue. ASCs could emerge as an effective and novel anti-aging therapeutic agent. However, extensive analysis of their actual effectiveness and mechanism of action are required.

Adipose-derived stem cells as a novel anti-aging therapy in cosmetic surgery: A concise review / Bertozzi, N.; Simonacci, F.; Grieco, M. P.; Grignaffini, E.; Raposio, E.. - In: EUROMEDITERRANEAN BIOMEDICAL JOURNAL. - ISSN 2279-7165. - 13:10(2018), pp. 46-56. [10.3269/1970-5492.2018.13.10]

Adipose-derived stem cells as a novel anti-aging therapy in cosmetic surgery: A concise review

Bertozzi N.;Simonacci F.;Grieco M. P.;Grignaffini E.;Raposio E.
2018-01-01

Abstract

Facial aging is a complex process and often poses a challenge for plastic and aesthetic surgeons. Injectable fillers and autologous adipose tissue are widely used for the restoration of soft tissue volume. However, lipotransfer currently lacks standardization and its unpredictable reabsorption rate remains an unresolved issue. Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells that could be responsible for the main rejuvenation capabilities of fat grafts. Currently, ASCs are administered in conjunction with autologous fat, while injectable vehicles such as hyaluronic acid, or other injectable biomaterials, are under study for the treatment of facial aging with promising results. Indeed, bioengineered fillers are at a very early stage of development, and could be further developed as semi-permanent fillers with biological properties of engrafted adipose tissue. ASCs could emerge as an effective and novel anti-aging therapeutic agent. However, extensive analysis of their actual effectiveness and mechanism of action are required.
2018
Adipose-derived stem cells as a novel anti-aging therapy in cosmetic surgery: A concise review / Bertozzi, N.; Simonacci, F.; Grieco, M. P.; Grignaffini, E.; Raposio, E.. - In: EUROMEDITERRANEAN BIOMEDICAL JOURNAL. - ISSN 2279-7165. - 13:10(2018), pp. 46-56. [10.3269/1970-5492.2018.13.10]
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2861882
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 4
  • ???jsp.display-item.citation.isi??? ND
social impact