to an impairment in the process of oxidative phosphorylation, responsible for the synthesis of ATP. MD may manifest at any age and in virtually any organ, although brain, skeletal muscle, liver and heart are most frequently involved because of their high-energy demand (mitochondrial encephalo-cardio-myopathies). Actually for the majority of these diseases no proven effective therapies exist. The aim of the project is evaluating the effects of thousands of chemical substances in different MD yeast models, previously characterized in our laboratory, to identify beneficial molecules for specific MD or with a general positive influence on mitochondrial functioning. For this aim we adopted an yeast-based screening called Drug Drop Test. Being all molecules tested FDA approved, this approach of drug repurposing accelerates the discovery of new therapeutics for MD. Some identified molecules have also shown beneficial effects in other model systems, including human cell lines. The confirmation of these positive preliminary data could lead to new pharmacological approaches for MD.

Saccharomyces cerevisiae as a system to discover beneficial molecules for mitochondrial diseases / DI PUNZIO, Giulia; CECCATELLI BERTI, Camilla; Pelosi, Federica; DI GREGORIO, Martina; Dallabona, Cristina; Claudia, Zanna; Baruffini, Enrico; Goffrini, Paola; Lodi, Tiziana; Donnini, Claudia. - (2018), pp. 168-168. ((Intervento presentato al convegno XV Congress of the Italian Federation of Life Sciences (FISV) tenutosi a Roma nel 18-21 settembre 2018.

Saccharomyces cerevisiae as a system to discover beneficial molecules for mitochondrial diseases

DI PUNZIO, GIULIA;Camilla Ceccatelli Berti;Federica Pelosi;Martina Di Gregorio;Cristina Dallabona;Enrico Baruffini;Paola Goffrini;Tiziana Lodi;Claudia Donnini
2018-01-01

Abstract

to an impairment in the process of oxidative phosphorylation, responsible for the synthesis of ATP. MD may manifest at any age and in virtually any organ, although brain, skeletal muscle, liver and heart are most frequently involved because of their high-energy demand (mitochondrial encephalo-cardio-myopathies). Actually for the majority of these diseases no proven effective therapies exist. The aim of the project is evaluating the effects of thousands of chemical substances in different MD yeast models, previously characterized in our laboratory, to identify beneficial molecules for specific MD or with a general positive influence on mitochondrial functioning. For this aim we adopted an yeast-based screening called Drug Drop Test. Being all molecules tested FDA approved, this approach of drug repurposing accelerates the discovery of new therapeutics for MD. Some identified molecules have also shown beneficial effects in other model systems, including human cell lines. The confirmation of these positive preliminary data could lead to new pharmacological approaches for MD.
Saccharomyces cerevisiae as a system to discover beneficial molecules for mitochondrial diseases / DI PUNZIO, Giulia; CECCATELLI BERTI, Camilla; Pelosi, Federica; DI GREGORIO, Martina; Dallabona, Cristina; Claudia, Zanna; Baruffini, Enrico; Goffrini, Paola; Lodi, Tiziana; Donnini, Claudia. - (2018), pp. 168-168. ((Intervento presentato al convegno XV Congress of the Italian Federation of Life Sciences (FISV) tenutosi a Roma nel 18-21 settembre 2018.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2861608
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact