Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.
Mechanisms of hypersensitivity reactions induced by drugs / Franceschini, Fabrizio; Bottau, Paolo; Caimmi, Silvia; Cardinale, Fabio; Crisafulli, Giuseppe; Liotti, Lucia; Saretta, Francesca; Bernardini, Roberto; Mori, Francesca; Caffarelli, Carlo. - In: ACTA BIO-MEDICA DE L'ATENEO PARMENSE. - ISSN 0392-4203. - 90:3S(2019), pp. 44-51. [10.23750/abm.v90i3-S.8160]
Mechanisms of hypersensitivity reactions induced by drugs
Caffarelli, Carlo
2019-01-01
Abstract
Adverse drug reactions include drug hypersensitivity reactions (DHRs), which can be immunologically mediated or non-immunologically mediated. The high number of DHRs unconfirmed and/or self-reported is a frequent problem in daily clinical practice, with considerable impact on future prescription choices and patient health. It is important to distinguish between hypersensitivity and non-hypersensitivity reactions by adopting a structured diagnostic approach to confirm or discard the suspected drug, not only to avoid life-threatening reactions, but also to reduce the frequent over-diagnosis of DHRs.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
