The substrate specificity of enzymes is bound to be imperfect, because of unavoidable physicochemical limits. In extant metabolic enzymes, furthermore, such limits are seldom approached, suggesting that the degree of specificity of these enzymes, on average, is much lower than could be attained. During biological evolution, the activity of a single enzyme with available alternative substrates may be preserved to a significant or even substantial level for different reasons – for example when the alternative reaction contributes to fitness, or when its undesirable products are nevertheless dispatched by metabolite repair enzymes. In turn, the widespread occurrence of promiscuous reactions is a consistent source of metabolic ‘messiness’, from which both liabilities and opportunities ensue in the evolution of metabolic systems.
The limits of enzyme specificity and the evolution of metabolism / Peracchi, Alessio. - In: TRENDS IN BIOCHEMICAL SCIENCES. - ISSN 0968-0004. - 43:12(2018), pp. 984-996. [10.1016/j.tibs.2018.09.015]
The limits of enzyme specificity and the evolution of metabolism
Peracchi, Alessio
2018-01-01
Abstract
The substrate specificity of enzymes is bound to be imperfect, because of unavoidable physicochemical limits. In extant metabolic enzymes, furthermore, such limits are seldom approached, suggesting that the degree of specificity of these enzymes, on average, is much lower than could be attained. During biological evolution, the activity of a single enzyme with available alternative substrates may be preserved to a significant or even substantial level for different reasons – for example when the alternative reaction contributes to fitness, or when its undesirable products are nevertheless dispatched by metabolite repair enzymes. In turn, the widespread occurrence of promiscuous reactions is a consistent source of metabolic ‘messiness’, from which both liabilities and opportunities ensue in the evolution of metabolic systems.File | Dimensione | Formato | |
---|---|---|---|
TIBS_2018_maintext_postprint.pdf
Open Access dal 01/01/2020
Descrizione: Articolo principale
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
756.46 kB
Formato
Adobe PDF
|
756.46 kB | Adobe PDF | Visualizza/Apri |
Peracchi Figure + Box2.pdf
Open Access dal 01/01/2020
Descrizione: Figure del testo principale
Tipologia:
Documento in Post-print
Licenza:
Creative commons
Dimensione
658.91 kB
Formato
Adobe PDF
|
658.91 kB | Adobe PDF | Visualizza/Apri |
Supplementary tables.pdf
Open Access dal 01/01/2020
Descrizione: Tabelle supplementari
Tipologia:
Altro materiale allegato
Licenza:
Creative commons
Dimensione
563.81 kB
Formato
Adobe PDF
|
563.81 kB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.