Intrathecal therapy with methotrexate and cytosine-arabinoside is a therapeutic strategy for maintaining remission in patients with acute lymphoblastic leukemia, that is associated with neurological side effects are described. We report a 4-year-old girl who became tetraplegic after the last dose of intrathecal therapy. Cerebrospinal fluid showed elevated protein level and nerve conduction study revealed a motor neuronopathy. Spine magnetic resonance imaging revealed gadolinium enhancement of the anterior roots of the cauda equina. We describe a myelopathy confined to the anterior horns and anterior spinal nerve roots without sensory involvement caused by intrathecal methotrexate. The pathogenesis of this selective involvement remains uncertain. © 2007 IOS Press. All rights reserved.

Acute motor neuropathy after intrathecal treatment with methotrexate: A case report / Pisani, Francesco; Scarano, Angela. - In: JOURNAL OF PEDIATRIC NEUROLOGY. - ISSN 1304-2580. - 5:3(2007), pp. 247-249. [10.1055/s-0035-1557383]

Acute motor neuropathy after intrathecal treatment with methotrexate: A case report

Pisani, Francesco;SCARANO, Angela
2007

Abstract

Intrathecal therapy with methotrexate and cytosine-arabinoside is a therapeutic strategy for maintaining remission in patients with acute lymphoblastic leukemia, that is associated with neurological side effects are described. We report a 4-year-old girl who became tetraplegic after the last dose of intrathecal therapy. Cerebrospinal fluid showed elevated protein level and nerve conduction study revealed a motor neuronopathy. Spine magnetic resonance imaging revealed gadolinium enhancement of the anterior roots of the cauda equina. We describe a myelopathy confined to the anterior horns and anterior spinal nerve roots without sensory involvement caused by intrathecal methotrexate. The pathogenesis of this selective involvement remains uncertain. © 2007 IOS Press. All rights reserved.
Acute motor neuropathy after intrathecal treatment with methotrexate: A case report / Pisani, Francesco; Scarano, Angela. - In: JOURNAL OF PEDIATRIC NEUROLOGY. - ISSN 1304-2580. - 5:3(2007), pp. 247-249. [10.1055/s-0035-1557383]
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2854745
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