The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis. Gastrin 17 (G-17) has been proposed as a non-invasive marker of GERD, due to the negative feedback between acid and the hormone. G17 levels seem able to identify patients with acid and non-acid reflux.

Diagnosis of GERD in typical and atypical manifestations / Cesario, Silvia; Scida, Serena; Miraglia, Chiara; Barchi, Alberto; Nouvenne, Antonio; Leandro, Gioacchino; Meschi, Tiziana; De' Angelis, Gian Luigi; Di Mario, Francesco. - In: ACTA BIO-MEDICA DE L'ATENEO PARMENSE. - ISSN 0392-4203. - 89:8-S(2018), pp. 33-39. [10.23750/abm.v89i8-S.7963]

Diagnosis of GERD in typical and atypical manifestations

Nouvenne, Antonio;Meschi, Tiziana;De' Angelis, Gian Luigi;Di Mario, Francesco
2018

Abstract

The manifestations of gastroesophageal reflux disease (GERD) have been recently classified into either esophageal or extra-esophageal syndromes. Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD. Endoscopy had a low sensitivity. Recently, the availability of multichannel intraluminal impedance and pH-monitoring (MII-pH) has modified the diagnostic approach towards atypical manifestations of GERD. There is a rising consensus that this technique should be considered as the gold standard for GERD diagnosis. Gastrin 17 (G-17) has been proposed as a non-invasive marker of GERD, due to the negative feedback between acid and the hormone. G17 levels seem able to identify patients with acid and non-acid reflux.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11381/2853885
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