Industrial workers are exposed to occupational pollutants, which may cause diseases such as cancer, but links to melanoma are not established. The identification of industry-related risk factors for melanoma incidence and mortality might be of importance for workers, health providers, and insurance companies. To assess melanoma incidence and mortality among oil/petroleum, chemical, and electrical industry workers. All studies reporting standardized mortality ratios (SMR) and/or standardized incidence ratios (SIR) of melanoma in workers employed in oil/petroleum, chemical, and electrical industries were included. Random-effect meta-analyses were carried out to summarize SIR and SMR for melanoma among oil/petroleum, chemical, and electrical industry workers. Heterogeneity was assessed using χ and I statistics. Possible source bias and quality were assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist and a modified version of the Newcastle-Ottawa scale. Of 1878 citations retrieved, we meta-analyzed 21, 6, and 9 studies for the oil/petroleum, electrical, and chemical industry, respectively. Oil/petroleum industry: summary standardized incidence ratio (SSIR)=1.23 [95% confidence interval (CI): 1.11-1.36, I=45%]; summary standardized mortality ratio (SSMR)=1.02 (95% CI: 0.81-1.28, I=48%); subgroups: SSIR=1.16 (95% CI: 1.01-1.32, I=15%), SSMR=1.19 (95% CI: 1.00-1.42, I=20%). Electrical industry: SSIR=1.00 (95% CI: 0.93-1.11, I=72%); SSMR=1.16 (95% CI: 0.74-1.81, I=11%). Chemical industry: SSIR=2.08 (95% CI: 0.47-9.24, I=73%); SSMR=2.01 (95% CI: 1.09-3.72, I=33%). Our meta-analysis suggests a slightly increased risk of developing melanoma among oil/petroleum industry workers and an increased melanoma mortality among oil/petroleum and chemical industry workers. No increased risks were found among electrical industry workers.

A meta-analysis of melanoma risk in industrial workers / Vujic, Igor; Gandini, Sara; Stanganelli, Ignazio; Fierro, Maria T; Rappersberger, Klemens; Sibilia, Maria; Tosti, Giulio; Ferrucci, Pier F; Caini, Saverio; De Felici, Maria B; Pagliarello, Calogero; Quaglino, Pietro; Sanlorenzo, Martina. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - 30:3(2020), pp. 286-296. [10.1097/CMR.0000000000000531]

A meta-analysis of melanoma risk in industrial workers

Stanganelli, Ignazio;De Felici, Maria B;Pagliarello, Calogero;
2020-01-01

Abstract

Industrial workers are exposed to occupational pollutants, which may cause diseases such as cancer, but links to melanoma are not established. The identification of industry-related risk factors for melanoma incidence and mortality might be of importance for workers, health providers, and insurance companies. To assess melanoma incidence and mortality among oil/petroleum, chemical, and electrical industry workers. All studies reporting standardized mortality ratios (SMR) and/or standardized incidence ratios (SIR) of melanoma in workers employed in oil/petroleum, chemical, and electrical industries were included. Random-effect meta-analyses were carried out to summarize SIR and SMR for melanoma among oil/petroleum, chemical, and electrical industry workers. Heterogeneity was assessed using χ and I statistics. Possible source bias and quality were assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist and a modified version of the Newcastle-Ottawa scale. Of 1878 citations retrieved, we meta-analyzed 21, 6, and 9 studies for the oil/petroleum, electrical, and chemical industry, respectively. Oil/petroleum industry: summary standardized incidence ratio (SSIR)=1.23 [95% confidence interval (CI): 1.11-1.36, I=45%]; summary standardized mortality ratio (SSMR)=1.02 (95% CI: 0.81-1.28, I=48%); subgroups: SSIR=1.16 (95% CI: 1.01-1.32, I=15%), SSMR=1.19 (95% CI: 1.00-1.42, I=20%). Electrical industry: SSIR=1.00 (95% CI: 0.93-1.11, I=72%); SSMR=1.16 (95% CI: 0.74-1.81, I=11%). Chemical industry: SSIR=2.08 (95% CI: 0.47-9.24, I=73%); SSMR=2.01 (95% CI: 1.09-3.72, I=33%). Our meta-analysis suggests a slightly increased risk of developing melanoma among oil/petroleum industry workers and an increased melanoma mortality among oil/petroleum and chemical industry workers. No increased risks were found among electrical industry workers.
A meta-analysis of melanoma risk in industrial workers / Vujic, Igor; Gandini, Sara; Stanganelli, Ignazio; Fierro, Maria T; Rappersberger, Klemens; Sibilia, Maria; Tosti, Giulio; Ferrucci, Pier F; Caini, Saverio; De Felici, Maria B; Pagliarello, Calogero; Quaglino, Pietro; Sanlorenzo, Martina. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - 30:3(2020), pp. 286-296. [10.1097/CMR.0000000000000531]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2852530
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