Background The 8th edition of TNM has introduced new rules for staging cutaneous melanoma. Objective To compare TNM 7th and 8th editions in defining pathological stages of melanoma. Methods A population-based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003-2012 has been used to measure the agreement (with Cohen's kappa) between TNM 8th and 7th editions in defining melanoma stage. Disease-specific survival has been computed for each stage according to TNM 7th and 8th. Results The agreement between the two TNM editions was quite good when considered on average (kappa = 70.7%), moderate for stage I (61.5%), nearly perfect for stage II (95.0%), but extremely poor for stage III (8.1%). The overall melanoma-specific observed survival was 90.8% at 5 year and 88.9% at 10 year with a strong prognostic effect of stage. Conclusion TNM 8th edition introduces several changes which do not seem really helpful in addressing the care of stage I melanoma and may complicate the definition and comparability of stage III.

Evaluation of the agreement between TNM 7th and 8th in a population-based series of cutaneous melanoma / Crocetti, Emanuele; Stanganelli, Ignazio; Mancini, Silvia; Vattiato, Rosa; Giuliani, Orietta; Ravaioli, Alessandra; Balducci, Chiara; Falcini, Fabio; Pimpinelli, Nicola. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 33:3(2019), pp. 521-524. [10.1111/jdv.15285]

Evaluation of the agreement between TNM 7th and 8th in a population-based series of cutaneous melanoma

Stanganelli, Ignazio;
2019-01-01

Abstract

Background The 8th edition of TNM has introduced new rules for staging cutaneous melanoma. Objective To compare TNM 7th and 8th editions in defining pathological stages of melanoma. Methods A population-based series of 1847 skin melanoma from Romagna cancer registry (Italy) incident during 2003-2012 has been used to measure the agreement (with Cohen's kappa) between TNM 8th and 7th editions in defining melanoma stage. Disease-specific survival has been computed for each stage according to TNM 7th and 8th. Results The agreement between the two TNM editions was quite good when considered on average (kappa = 70.7%), moderate for stage I (61.5%), nearly perfect for stage II (95.0%), but extremely poor for stage III (8.1%). The overall melanoma-specific observed survival was 90.8% at 5 year and 88.9% at 10 year with a strong prognostic effect of stage. Conclusion TNM 8th edition introduces several changes which do not seem really helpful in addressing the care of stage I melanoma and may complicate the definition and comparability of stage III.
Evaluation of the agreement between TNM 7th and 8th in a population-based series of cutaneous melanoma / Crocetti, Emanuele; Stanganelli, Ignazio; Mancini, Silvia; Vattiato, Rosa; Giuliani, Orietta; Ravaioli, Alessandra; Balducci, Chiara; Falcini, Fabio; Pimpinelli, Nicola. - In: JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY. - ISSN 0926-9959. - 33:3(2019), pp. 521-524. [10.1111/jdv.15285]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2852205
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