The development of innovative nanosystems paves the way to multidisciplinary applications at the frontier between materials science and nanomedicine. In this work we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer belonging to the class of porphyrins. We show that the bare nanowires do not elicit either midterm (72 h) or long-term (10 days) cytotoxic activity leading to irreversible cellular damages or death. The hybrid nanosystem upon irradiation with 6 MV X-Rays at low doses (0.4-2 Gy) is able to generate singlet oxygen, acting therefore as an effective agent for X-Ray-excited photodynamic therapy exploitable to treat deep-seated tumors. In-vitro tests on lung adenocarcinoma cells show that the nanosystem enhances the effects of radiation therapy. As evaluated by clonogenic survival assay 12 days after irradiation at a dose of 2 Gy, the cell population is reduced with respect to control cells by about 75%.

Cytocompatible SiC/SiOx nanowires for X-ray-excited photodynamic therapy / Rossi, F.; Ravanetti, F.; Bedogni, E.; Lagonegro, P.; Fabbri, F.; Rimoldi, T.; Pinelli, S.; Alinovi, R.; Benecchi, G.; Cacchioli, A.; Cristofolini, L.; Bigi, F.; Salviati, G.. - ELETTRONICO. - (2018), pp. 141-145. (Intervento presentato al convegno 1st Workshop on Nanotechnology in Instrumentation and Measurement, NANOFIM 2015 tenutosi a Lecce nel 2015) [10.1109/NANOFIM.2015.8425366].

Cytocompatible SiC/SiOx nanowires for X-ray-excited photodynamic therapy

F. Rossi
;
F. Ravanetti;E. Bedogni;P. Lagonegro;F. Fabbri;T. Rimoldi;S. Pinelli;R. Alinovi;G. Benecchi;A. Cacchioli;L. Cristofolini;F. Bigi;G. Salviati
2018-01-01

Abstract

The development of innovative nanosystems paves the way to multidisciplinary applications at the frontier between materials science and nanomedicine. In this work we present a novel hybrid nanosystem based on cytocompatible inorganic SiC/SiOx core/shell nanowires conjugated via click-chemistry procedures with an organic photosensitizer belonging to the class of porphyrins. We show that the bare nanowires do not elicit either midterm (72 h) or long-term (10 days) cytotoxic activity leading to irreversible cellular damages or death. The hybrid nanosystem upon irradiation with 6 MV X-Rays at low doses (0.4-2 Gy) is able to generate singlet oxygen, acting therefore as an effective agent for X-Ray-excited photodynamic therapy exploitable to treat deep-seated tumors. In-vitro tests on lung adenocarcinoma cells show that the nanosystem enhances the effects of radiation therapy. As evaluated by clonogenic survival assay 12 days after irradiation at a dose of 2 Gy, the cell population is reduced with respect to control cells by about 75%.
2018
9781509051519
Cytocompatible SiC/SiOx nanowires for X-ray-excited photodynamic therapy / Rossi, F.; Ravanetti, F.; Bedogni, E.; Lagonegro, P.; Fabbri, F.; Rimoldi, T.; Pinelli, S.; Alinovi, R.; Benecchi, G.; Cacchioli, A.; Cristofolini, L.; Bigi, F.; Salviati, G.. - ELETTRONICO. - (2018), pp. 141-145. (Intervento presentato al convegno 1st Workshop on Nanotechnology in Instrumentation and Measurement, NANOFIM 2015 tenutosi a Lecce nel 2015) [10.1109/NANOFIM.2015.8425366].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11381/2850899
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