This review focuses upon interactions and potential therapeutic targets in the 'vicious cycle' between hypoxia and neoangiogenesis following treatment of hepatocellular carcinoma with transarterial loco-regional therapies. Biomarkers correlated with angiogenesis have been studied by many authors as prognostic determinants following transarterial intrahepatic therapy. According to these results future therapies directed toward specific factors related to angiogenesis could play a significant role in preventing local tumor recurrence and remote metastasis.
Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments / Petrillo, Mario; Patella, Francesca; Pesapane, Filippo; Suter, Matteo B; Ierardi, Anna M; Angileri, Salvatore A; Floridi, Chiara; de Filippo, Massimo; Carrafiello, Gianpaolo. - In: FUTURE ONCOLOGY. - ISSN 1479-6694. - 14:28(2018), pp. 2957-2967. [10.2217/fon-2017-0739]
Hypoxia and tumor angiogenesis in the era of hepatocellular carcinoma transarterial loco-regional treatments
de Filippo, Massimo;
2018-01-01
Abstract
This review focuses upon interactions and potential therapeutic targets in the 'vicious cycle' between hypoxia and neoangiogenesis following treatment of hepatocellular carcinoma with transarterial loco-regional therapies. Biomarkers correlated with angiogenesis have been studied by many authors as prognostic determinants following transarterial intrahepatic therapy. According to these results future therapies directed toward specific factors related to angiogenesis could play a significant role in preventing local tumor recurrence and remote metastasis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
